If you use opioid medicine such as oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks. If you become pregnant while taking oxycodone, do not Sober living house stop your medication suddenly without talking to your doctor.
Clinical Pharmacology for Oxycontin
- Oxycodone extended-release tablets and extended-release capsules are used to relieve severe pain in people who are expected to need pain medication around the clock for a long time and who cannot be treated with other medications.
- Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Titrate the dosage of OXYCONTIN slowly in geriatric patients and frequently reevaluate the patient for signs of central nervous system and respiratory depression.
- This means they may cover only one of the drugs or only generic forms.
- Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
- Oxycodone is extensively metabolized by multiple metabolic pathways to produce noroxycodone, oxymorphone and noroxymorphone, which are subsequently glucuronidated.
A multimodal approach to pain management may optimize the treatment of chronic pain, as well as assist with the successful tapering of the opioid analgesic see WARNINGS AND PRECAUTIONS and Drug Abuse And Dependence. It is important to ensure ongoing care of the patient and to agree on an appropriate tapering schedule and follow-up plan so that patient and provider goals and expectations are clear and realistic. When opioid analgesics are being discontinued due to a suspected substance use disorder, evaluate and treat the patient, or refer for evaluation and treatment of the substance use disorder. Treatment should include evidence-based approaches, such as medication assisted treatment of opioid use disorder. Complex patients with comorbid pain and substance use disorders may benefit from referral to a specialist. “Drug-seeking” behavior is very common in persons with substance use disorders.
- Oxycodone concentrated solution should only be used to treat people who are tolerant (used to the effects of the medication) to opioid medications because they have taken this type of medication for at least one week.
- Other metabolites (α- and ß-oxycodol, noroxycodol and oxymorphol) may be present at very low concentrations and demonstrate limited penetration into the brain as compared to oxycodone.
- OxyContin is a brand-name version of the extended-release form of oxycodone.
- Do not abruptly discontinue OXYCONTIN in a patient physically dependent on opioids.
Patient resources
Do not take more than one dose of the extended-release tablets or capsules in 12 hours. Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with oxycodone increases the risk that you will experience serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment.
What happens if I miss a dose?
Hyperalgesia is when your body becomes more sensitive to pain and can cause things that normally cause pain to feel more painful than usual. Allodynia is a condition where things that do not usually cause you pain, such as wearing glasses or brushing your hair, cause you pain. Call your health care provider if you are having more pain, pain from things that would normally not cause you pain, or pain in other parts of your body. People who are predisposed to drug use may like the way pain relieves their stress or masks mental health symptoms or trauma. Both OxyContin and oxycodone can lead to physical https://ecosoberhouse.com/ dependence and addiction if taken in high doses or for extended periods of time.
What Drugs, Substances, or Supplements Interact with OxyContin?
A class of drugs is a group of medications that work in a similar way and are often used to treat similar conditions. Immediate-release oxycodone and OxyContin both bind to receptors in your brain and spinal cord. OxyContin exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Each person should be assessed for risk prior to prescribing OxyContin and monitored regularly for the development of these behaviors and conditions. There is a relationship between increasing oxycodone plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression. In opioid-tolerant patients, the situation may be altered by the development of tolerance to opioid-related adverse reactions see DOSAGE AND ADMINISTRATION.
What should I do if I accidentally use too much oxycodone?
Inform patients that OXYCONTIN may cause orthostatic hypotension and syncope. If concomitant use is warranted, consider prescribing naloxone for the emergency treatment of opioid overdose see DOSAGE AND ADMINISTRATION, Life-Threatening Respiratory Depression and OVERDOSE. Abuse or misuse of OXYCONTIN by crushing, chewing, snorting, or injecting the dissolved product will result in the uncontrolled delivery of oxycodone and can result in overdose and death see OVERDOSE. Infants born to mothers physically dependent on opioids will also be physically dependent and may exhibit respiratory difficulties and withdrawal signs see Use In Specific Populations. OXYCONTIN contains oxycodone, a substance with high potential for misuse and abuse, which can lead to the development of substance use disorder, including addiction see WARNINGS AND why is oxy so addictive PRECAUTIONS. The concomitant use of OXYCONTIN and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects.